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Echo
Cannabis Sacrament Minister
Joined: 14 Apr 2003
Posts: 1899
Location: England
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 Posted: Sat Oct 18, 2003 8:35 pm Post subject: THC-Treated rats lived longer! |
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Medical Marijuana:
Unpublished Federal Study
Found THC- Treated Rats
Lived Longer,
Had Less Cancer
by John S. James
AIDS Treatment News has obtained a 126-page draft report of a major toxicology study of THC, the main psychoactive ingredient of marijuana. The study was completed over two and a half years ago, and passed peer review for publication, but has been kept quiet until this month, when someone leaked copies of the draft report. As far as we know, the public has never been told about this research -- for example, the drug- reform movement seems not to have known about its existence. This work may have been hushed because its findings are not what the drug-war industry would want.
The study gave huge doses of THC to rats and mice by stomach tube, and looked for cancers and other evidence of toxicity. First there were small toxicity studies, which used enough THC to kill some of the animals; later, two-year studies were run in both rats and mice, using doses which were still much higher than those of marijuana smokers. The two-year studies tested THC in several hundred rats and several hundred mice.
In rats, those given THC had a clear survival advantage over the untreated controls; this effect was statistically significant in all dose groups, and in both males and females. In mice (which were given much larger doses than the rats relative to body weight) there was no survival difference among the groups -- except that those given the highest dose (which was close to the lethal dose for mice) had worse survival.
In both mice and rats, in both males and females, "the incidence of benign and malignant neoplasms ... were decreased in a dose-dependent manner" -- meaning that the more THC the animals were given, the fewer tumors they developed.
The treated animals weighed less than the controls (even though both ate about the same amount of food); the researchers speculated that the lower body weight may have partly accounted for the increased survival and reduced tumors in the THC-treated animals.
The doses were large enough to cause seizures and convulsions in many of the animals, especially when they were dosed or handled. These did not start immediately, but after many weeks, depending on the dose. The researchers looked for brain lesions in animals which had seizures, but found none.
No evidence of carcinogenic activity in the rats, but there was "equivocal evidence" of one kind of thyroid tumor in the mice -- with no evidence of a dose-dependent response. Other tumors were less common in the treated animals than in the controls -- except in one case, which the toxicologists believed was due to the fact that the treated animals lived longer, and therefore had more opportunity to develop tumors.
The report includes a professionally objective review of the biological effects, possible toxicities, and possible medical uses of THC and marijuana.
The title of the report is "NTP Technical Report on the Toxicology and Carcinogenesis Studies of 1-Trans-Delta(9)- Tetrahydrocannabinol (CAS No. 1972-08-3) in F344/N Rats and B6C3F(1) Mice (Gavage Studies)." Over 35 researchers contributed to this study, and 12 others reviewed their work; several institutions, including the National Toxicology Program and SRI International, were involved. The document we received is report NTP TR 446, NIH Publication No. 94-3362, of the U.S. Department of Health and Human Services. ("NTP" stands for National Toxicology Program, which is made up of four Federal agencies within Health and Human Services.) Each page of the draft is stamped "not for distribution or attribution." In addition to the 126-page document we have reviewed here, there are 11 appendices, which we have not seen.
According to the draft, the report will be available from NTP Central Data Management, 919/ 541-3419. AIDS Treatment News requested a copy of the final report when it is ready, and also requested a copy of the draft. Now that the existence of the report has become publicly known, we have heard that draft copies are being sent if requested -- despite the notice on each page not to distribute them.
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| Tom Petty wrote: |
Well I know what’s right, I got just one life
In a world that keeps on pushin’ me around
But I’ll stand my ground and I won’t back down
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Ferre
Cannabis Sacrament Minister.
Joined: 14 Apr 2003
Posts: 7295
Location: Amsterdam
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| Posted: Sat Oct 18, 2003 8:45 pm Post subject: |
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I knewit! 
Cannabis makes you stay(feel?) younger, that's my personal experiance.
Btw I volunteer for tests on humans. 
*Rolls another  .
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█ Please read the Board Rules and Posting, and you
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People who know truth, speak truth.
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Urbanhog
moderator
Joined: 22 Apr 2003
Posts: 338
Location: Tropical Queensland, Australia
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| Posted: Mon Oct 20, 2003 5:13 am Post subject: |
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I volunteer too! maybe they should have two experiment groups? one for tokers and one for who consume them and compare the results? they will need to make my bed comfty if they want to experiement me while I eat endless mj cookies 
_________________
"Travel is fatal to prejudice, bigotry, and narrow-mindedness, and many of our people need it sorely on these accounts. Broad, wholesome, charitable views of men and things cannot be acquired by vegetating in one little corner of the earth all one's lifetime."
--Mark Twain, The Innocents Abroad (1869) |
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Echo
Cannabis Sacrament Minister
Joined: 14 Apr 2003
Posts: 1899
Location: England
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| Posted: Mon Oct 20, 2003 5:39 pm Post subject: |
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I have just harvested my outdoor plant and she is now hanging down in my garage for drying. This morning I have fed my chinchilla some big leaves I won't be using for my own needs and the chinchilla seemed to like those a lot. They were supposed to be a treat only, but he seems to like them more than his highly nutricious alpha alpha pellets. And I am sure I am giving my pet the BEST I can. He'll have a long happy life 
Echo
_________________
| Tom Petty wrote: |
Well I know what’s right, I got just one life
In a world that keeps on pushin’ me around
But I’ll stand my ground and I won’t back down
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Last edited by Echo on Fri Oct 24, 2003 1:20 pm; edited 1 time in total |
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tellme
regular contributor
Joined: 27 Sep 2003
Posts: 33
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| Posted: Thu Oct 23, 2003 6:20 pm Post subject: |
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| My 15 years old son harvested his outdoor plants , our Rabbits love the big leaves too, more then their normal food. |
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Urbanhog
moderator
Joined: 22 Apr 2003
Posts: 338
Location: Tropical Queensland, Australia
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| Posted: Fri Oct 24, 2003 6:48 am Post subject: |
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LOL @ tellme about the rabbits
My state, Queensland in Australia is illegal to have rabbits and ferrets as pets..... I am not kidding. 
Few years back Australia had a really bad wild rabbit problems and they somehow managed to wipe the population with some disease introduced to the bunnies then QLD changed laws to make rabbits illegal as pets, and I am not sure why ferrets are illegal.... maybe something to do with them get lose and lost in the forst and destory the Australian native flora/animals.
_________________
"Travel is fatal to prejudice, bigotry, and narrow-mindedness, and many of our people need it sorely on these accounts. Broad, wholesome, charitable views of men and things cannot be acquired by vegetating in one little corner of the earth all one's lifetime."
--Mark Twain, The Innocents Abroad (1869) |
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David
Bard
Joined: 28 Sep 2003
Posts: 1261
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| Posted: Sat Mar 27, 2004 11:02 am Post subject: |
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